You Get Six Portals For Every Map – Use 'em Or Lose 'em
In the endgame, when you activate a Waystone for a map on the Atlas, six portals will appear around you in the Ziggurat Refuge. Each portal represents one time you can use a Town Portal to return to the Refuge – a chance to refresh your Flasks and Charms, clean inventory space, and re-tool your build for the challenges of the map.
When you die in a map, the portals will all close, and you must use another Waystone to go back and try it again (if you haven't bricked the map node). There's no benefit to leaving Portals open at the end of a map, so don't be afraid to head back to Town if you are low on resources. Even a quick stop back to Town could mean the difference between finishing and failing a map.
Keep An Extra Gear With Elemental Resistances
As you progress through the campaign, your Elemental Resistances will be penalized and compound across all Acts (and Cruel difficulty). By the time you reach the Atlas Elemental Resistances need to become a major priority for modifiers on your gear thanks to this creeping debuff and the sheer power of enemies in the endgame.
Though you should normally try to normalize your Elemental Resistances to suit most situations, certain maps and enemy types can be countered with high, but specific, Resistances. An buy poe 2 currency with lots of Fire enemies is easy with high Fire Resistance, an area with lots of Poison enemies is easier with high Poison defense stats, and so on.
If you find a piece of gear with a high Resistance to a specific Element, keep it in your Stash. You never know when you'll run into a map filled with enemies that inflict 200% Freeze and Cold damage, when a highly-tailored set of equipment with Cold resistance will do a lot more for your survivability path of exile 2 currency for sale combat modifiers.
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If you want to know more, you can read this article: Woolie’s Armor Break Warbringer Build in Path of Exile 2: A Powerful Melee Guide